Architect from Ferrara, in 1467 he started working on Palazzo Schifanoia under the direction of Pietro Benevenuti degli Ordini. In 1483 he took his place as military engineer and ducal architect.

For a long time, he was forgotten by art historians until in the 60s Bruno Zevi and his architecture school defined him as one of the most genius architects of the Renaissance. His personality and techniques are still being studied, but the huge contribution he gave to Ferrara's looks is obvious. In 1492 his biggest challenge began: designing new neighbourhoods north of the city walls. This part was called Erculean Addition because of the duke who ordered it, Ercole I. He directed the works for more than ten years and became friends with the duke. Overall, he gave Ferrara that uniform look that made it, according to Burkhard, the first modern city in Europe. After Ercole I's death in 1505, he started working for cardinal Ippolito I d'Este, but kept working on the walls and some villas spread around the area.